Los Angeles Chargers vs. San Francisco 49ers picks, predictions: Who wins NFL Week 10 game?

Jeremy Cluff
Arizona Republic

The Los Angeles Chargers and San Francisco 49ers play on Sunday in a game on the NFL Week 10 schedule.

Which team will get the victory?

Check out these NFL Week 10 picks and predictions for the game, which can be seen at 6:20 p.m. MST on NBC.

The 49ers are a 6.5-point favorite in the game.

NFL Week 10 picks, predictions:

The Arizona Republic: 49ers 30, Chargers 20

Jeremy Cluff writes: Injuries have decimated the Chargers' offense. It will show against the 49ers' defense. Bet the 49ers to cover vs. Chargers

Bill Speros writes: "San Francisco is coming off the bye while the Chargers have a quick turnaround after a hard-fought win at Atlanta. That makes this line appealing. As does the fact that the 49ers four wins this season have come by an average of 18.5 points."

NFL Week 10 odds:

Will Christian McCaffrey and the San Francisco 49ers beat the Los Angeles Chargers in NFL Week 10?

ESPN: 49ers have a 71.8% chance to win the Week 10 game

The site gives the Chargers a 27.9% chance to get the victory.

Draft Kings: Take the 49ers to cover vs. Chargers

It writes: "Assuming San Francisco gets its key guys healthy again after the bye, this team will be hard to stop. The 49ers should be dynamic offensively and disruptive defensively, even with Jimmy Garoppolo’s inconsistent play. The Chargers have a lot of injuries as well and have struggled against good defenses."

How to watch:NFL Week 10 schedule, television information

Sports Betting Dime: 49ers 25.5, Chargers 16.6

The site's formula predicts that the 49ers will win the Week 10 NFL game.

Fansided: 49ers 27, Chargers 17

Peter Panacy writes: "One might figure McCaffrey dazzles against a suspect Chargers defense, and while that could mean an offensive shootout is in play, the Niners’ own defense expecting to get healthier should be able to limit the damage Herbert and his own playmakers try to do. Los Angeles doesn’t have that benefit, which heavily influences our opening prediction that calls for a 27-17 victory for San Francisco."

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Reach Jeremy Cluff at Follow him on Twitter @Jeremy_Cluff.

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