NFL Week 10 picks, predictions for Vikings vs. Bills, Chargers vs. 49ers, other games

Jeremy Cluff
Arizona Republic

The NFL Week 10 schedule has some interesting games.

Which teams will get victories in those games?

Check out The Arizona Republic's picks and predictions for each game on the Week 10 NFL schedule.

Click on each game for picks and predictions for that game from other sites. All times MST. 

NFL Week 10 odds:

Thursday Night Football schedule

Atlanta Falcons vs. Carolina Panthers, 6:15 p.m., Amazon Prime Video

These two teams played a thriller in Week 8, with the Falcons winning 37-34 in overtime. It won't be quite as close this time.

Prediction: Falcons 24, Panthers 17

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Sunday early football games

Seattle Seahawks vs. Tampa Bay Buccaneers, 7:30 a.m., NFL Network

The Buccaneers are favored in this game, but we really like how Geno Smith and the Seahawks are playing. Give us Seattle in an upset.

Prediction: Seahawks 27, Buccaneers 21

Minnesota Vikings vs. Buffalo Bills, 11 a.m., Fox

Will this be the game of the week? These teams have just three losses between them. We like the Bills to bounce back in a close one.

Prediction: Bills 24, Vikings 21

Detroit Lions vs. Chicago Bears, 11 a.m., Fox

Justin Fields has become must-see TV in recent weeks. We don't think the Lions will be able to contain him.

Prediction: Bears 30, Lions 20

Jacksonville Jaguars vs. Kansas City Chiefs, 11 a.m., CBS

The Chiefs needed overtime to beat the Titans in Week 9. We don't anticipate this game being nearly as close.

Prediction: Chiefs 35, Jaguars 17

NFL Week 10 picks, predictions:

Cleveland Browns vs. Miami Dolphins, 11 a.m., CBS

We really like the way Tua Tagovailoa is playing right now. This game could see a lot of points.

Prediction: Dolphins 35, Browns 31

Houston Texans vs. New York Giants, 11 a.m., CBS

It hasn't been pretty, but the Giants are having a special season. It isn't over yet, either.

Prediction: Giants 20, Texans 13

New Orleans Saints vs. Pittsburgh Steelers, 11 a.m., Fox

We don't have confidence In either of these teams, but we have more confidence in the Saints.

Prediction: Saints 21, Steelers 13

Denver Broncos vs. Tennessee Titans, 11 a.m., CBS

We like the Titans' chances to bounce back at home, with or without Ryan Tannehill at quarterback.

Prediction: Titans 28, Broncos 24

How to watch:NFL Week 10 schedule, television information

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Sunday late football games

Indianapolis Colts vs. Las Vegas Raiders, 2:05 p.m., CBS

Frankly, we're shocked both of these teams are this bad. The home team should be able to bounce back here, barely.

Prediction: Raiders 24, Colts 23

Dallas Cowboys vs. Green Bay Packers, 2:25 p.m., Fox

The Packers have to win sometime, right? It just isn't going to be in Week 10 against a rested Cowboys team.

Prediction: Cowboys 31, Packers 21

Arizona Cardinals vs. Los Angeles Rams, 2:25 p.m., Fox

Both of these teams should be far better than they are right now. At least the Rams and their fans have a Super Bowl title to fall back on.

Prediction: Rams 27, Cardinals 17

Super Bowl odds:NFL Week 10 betting odds for every NFL team to win 2023 Super Bowl

Sunday Night Football schedule

Los Angeles Chargers vs. San Francisco 49ers, 6:20 p.m., NBC

Injuries have decimated the Chargers' offense. It will show against the 49ers' defense.

Prediction: 49ers 30, Chargers 20

Monday Night Football schedule

Washington Commanders vs. Philadelphia Eagles, 6:15 p.m., ESPN

How long can the Eagles keep the magic going? They shouldn't have any problem moving to 9-0 this week.

Prediction: Eagles 38, Commanders 21

NFL Week 10 odds:Point spreads, moneylines, over/unders, totals for Week 10 NFL games

Reach Jeremy Cluff at Follow him on Twitter @Jeremy_Cluff.